With modern methods, researchers can produce potential disease treatments faster than ever. So why do they take so long to get to the market?
Flow cytometry is one of the most common clinical and lab testing methods used to detect markers in suspension media. This highly efficient technique can examine thousands of blood cells per second, with potential to identify more than 28 types of cell structures simultaneously. Testing on cells – lots of them – and looking for changes in just a tiny fraction of them is like searching for a needle in a haystack. Ultimately, the equipment capabilities are constrained by the brightness of the fluorescence signals.
Although the equipment is physically designed to run 28 colors, only a few are practically used due to 1) Spectral overlap, otherwise referred to as “spillover” in the industry and 2) “auto-fluorescence”, the inherent background fluorescence produced by surrounding bio-structures.
NovoLux makes “high-brightness dyes”™ at least 10x brighter than any commercial product in the industry with substantially sharper peaks, virtually eliminating the spillover and auto-fluorescence problems with other dyes. This allows the instrument to detect signals from any color without instrument modifications. Also, NovoLux's dyes have a novel feature, tunable brightness, meaning the precise increase in brightness of a single color for low abundance cells can be made without affecting other signals. This allows researchers to detect what was previously undetectable.
Our product differentiators include high-brightness, sharp peaks, tunable brightness for specific cells, a drop-in technology compatible with existing instrumentation, excellent water solubility, ease of conjugation, and chemical and photo stability.